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BAY 80-6946

(CAS: 1032568-63-0)

Suppliers of BAY 80-6946

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

Fax: Purity: Brand:

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Price and Availability: USD180/5mg ()

Aladdin [email protected] 400 620 6333 China

Fax: 021 5102 6000Purity: Brand:

Price and Availability: RMB13212/5Omg ()

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD190/5mg (In stock)

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

Fax: +1 (847) 367-3681Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: 0.98 Brand: BOC Sciences

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

Fax: 408-493-1801Purity: Brand:

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD180/5mg () USD288/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD180/5mg () USD288/10mg ()
Quality Control & MSDS Files: HNMR NP-HPLC MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Price and Availability: USD190/5mg ()
Quality Control & MSDS Files: CoA HNMR HPLC MSDS

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD270/5mg (In stock) USD370/10mg (In stock) USD1070/50mg (In stock) USD2470/200mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD180/5mg () USD288/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD120/2mg () USD172/5mg () USD254/10mg () USD471/25mg () USD628/50mg ()

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Background Information of BAY 80-6946

BAY 80-6946 is a potent and highly selective reversible PI3K inhibitor for PI3Kα/β with IC50 of 0.469 nM/3.72 nM. IC50 value: 0.469/3.72 nM(PI3Kα/β) [1] Target: PI3Kα/β in vitro: BAY 80-6946 is a phosphoinositide 3-kinase (PI3K) inhibitor with potential antineoplastic activity.

Solubility of BAY 80-6946

Solubility Sources
DMSO MedChemexpress Co., Ltd.
(25°C) * In vitro 10% Trifluoroacetic acid water solution 1 mg/mL (2.08 mM); Ethanol0.01 mg/mL (0.02 mM); DMSO0.002 mg/mL (0.0 mM); In vivo 10% Trifluoroacetic acid water solution1mg/mL Selleck Chemicals LLC

Storage Condition of BAY 80-6946

Storage Condition Sources
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.
MedKoo Biosciences, Inc.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [NP-HPLC] MedChemexpress Co., Ltd.
[CoA] [HNMR] [HPLC] MedKoo Biosciences, Inc.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways PI3K/Akt/mTOR
Target PI3K
Research Area Cancer
Indications Non-Hodgkin lymphoma Metastasis Advanced solid tumor

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
BAY 80-6946 Bayer AG Non-Hodgkin lymphoma 2012/11/30 2017/7/31 Phase 2 Clinical
BAY 80-6946 Bayer AG Metastasis 2011/7/31 2014/7/31 Phase 1 Clinical
BAY 80-6946 Bayer AG Advanced solid tumor 2011/11/30 2013/12/31 Phase 1 Clinical
BAY 80-6946 Bayer AG Metastasis 2011/8/31 2014/5/31 Phase 1 Clinical
BAY 80-6946 Bayer AG Advanced solid tumor 2011/8/31 2012/7/31 Phase 1 Clinical
BAY 80-6946 - Phase 3

Chemical Information

M.Wt Formula CAS No. Synonyms
480.52 C23H28N8O4 1032568-63-0 BAY80-6946; 2-amino-N-(7-methoxy-8-(3-morpholinopropoxy)-2,3-dihydroimidazo[1,2-c]quinazolin-5-yl)pyrimidine-5-carboxamide

Structure Information of BAY 80-6946

Smiles O=C(C1=CN=C(N)N=C1)NC2=NC3=C(OC)C(OCCCN4CCOCC4)=CC=C3C5=NCCN25
InChI InChI=1S/C23H28N8O4/c1-33-19-17(35-10-2-6-30-8-11-34-12-9-30)4-3-16-18(19)28-23(31-7-5-25-20(16)31)29-21(32)15-13-26-22(24)27-14-15/h3-4,13-14H,2,5-12H2,1H3,(H2,24,26,27)(H,28,29,32)

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Chemical and Physical Properties

Appearance:Light brown to brown solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:10% Trifluoroacetic acid water solution,1 mg/mL(2.08 mM);In vitro:Ethanol,0.01 mg/mL(0.02 mM);In vitro:DMSO,0.002 mg/mL(0.0 mM);In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):10% Tri
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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