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Nepafenac

(CAS: 78281-72-8)

Suppliers of Nepafenac

Company Name Email Tel Country
Apichem Chemical Technology Co., Ltd. [email protected],[email protected] +86 (21) 6199-2249 China

Fax: +86 (21) 5196-9751Purity: Brand:

Asia Talent Chemical Limited [email protected],[email protected],[email protected] +86 (755) 8665-5561 China

Fax: +86 (755) 8665-5591Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: Brand: BOC Sciences

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: >98% Brand:

Carbosynth Limited [email protected] +44 (1635) 578-444

Fax: +44 (1635) 579-444Purity: Brand:

Price and Availability: USD65/50mg ()

Combliss Healthcare Industrial Ltd. [email protected],[email protected] +86 18615688656 China

Fax: Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: >98% Brand:

Price and Availability: USD50/10mg (In stock) USD120/50mg (In stock) USD200/100mg (In stock)
Quality Control & MSDS Files: HNMR LCMS

Nanjing Qihui Pharmtehc Co., Ltd. [email protected] +86 (25) 5855-7899 China

Fax: +86 (25) 5855-7899Purity: Brand:

Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

Fax: 214-358-6070Purity: Brand:

Price and Availability: USD240/10mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: >98% Brand:

Price and Availability: USD120/10mg (In stock) USD210/25mg (In stock) USD770/100mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: >98% Brand:

Price and Availability: USD110/10mg (Get quote) USD400/50mg (Get quote) USD660/100mg (Get quote)

Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

Fax: Purity: Brand:

Price and Availability: USD55/10mg ()

Suzhou Chemwe, Inc. [email protected] +86 (512) 6270-6911 / +86 13812802656 China

Fax: +86 (512) 6270-6910Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .99 Brand: TargetMol

Price and Availability: USD38/2mg () USD73/10mg () USD114/25mg ()

Thompson Biological Technology Co., Ltd. [email protected] +86 (10) 5248-8336 China

Fax: Purity: Brand:

Tokyo Chemical Industry Co., Ltd. [email protected] 03-3668-0489 Japan

Fax: 03-3668-0520Purity: Brand:

Price and Availability: USD119/200mg ()

ZHIYU Biotechnology Co., Ltd. [email protected],[email protected] +86 (512) 6279-1916 / +86 18912796596 China

Fax: +86 (512) 6279-1915Purity: Brand:

Zhejiang Esun Chemical Co., Ltd. [email protected] +86 (571) 5628-6531 China

Fax: +86 (571) 5628-7608Purity: Brand:

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Background Information of Nepafenac

Nepafenac(AHR 9434; AL 6515; Nevanac) is a selective COX-2 inhibitor; is prodrug of Amfenac. IC50 value: Target: COX-2 Nepafenac is a NSAID (nonsteroidal anti inflammatory drug) that is routinely used in opthamology to control pain following cataract surgery.

Solubility of Nepafenac

Solubility Sources
DMSO Methanol MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 50 mg/mL (196.63 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Nepafenac

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Immunology/Inflammation
Target COX
Research Area Inflammation/Immunology
Indications Macular edema Pain Ocular pain Cataract

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Nepafenac University of California Macular edema 2013/10/31 2014/10/01 Phase 4 Clinical
Nepafenac Virdi Eye Clinic Pain 2011/5/31 2012/5/31 Phase 4 Clinical
Nepafenac Queen's University Macular edema 2010/2/28 2011/5/31 Phase 4 Clinical
Nepafenac Santa Casa de Misericordia de Santos Ocular pain 2009/3/31 2009/8/31 Phase 4 Clinical
Nepafenac Clinica Oftamologica Zona Sul Cataract 2009/3/31 2011/8/31 Phase 4 Clinical
Nepafenac - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
254.28 C15H14N2O2 78281-72-8 AHR 9434;AL 6515;Nevanac;AHR9434;AHR-9434;AL6515;AL-6515; 2-(2-amino-3-benzoylphenyl)acetamide

Structure Information of Nepafenac

Smiles O=C(N)CC1=CC=CC(C(C2=CC=CC=C2)=O)=C1N
InChI InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)

Related Products

Other Form Products of Nepafenac

Name CAS Formula Suppliers
Nepafenac-d5 1246814-53-8 C15H14N2O2 6

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Chemical and Physical Properties

Appearance:Light yellow to yellow Solid Melting point:177-181°C
Boiling point: Flash Point:
Water Solubility: Solubility:
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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