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Tiotropium (Bromide)

(CAS: 136310-93-5)

Suppliers of Tiotropium (Bromide)

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Abcam [email protected] (888) 77-ABCAM (22226) USA

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Price and Availability: USD175/5mg ()

Alfa Chemistry [email protected] 1-201-478-8534 USA

Fax: 1-516-927-0118Purity: 0.96 Brand: Alfa Chemistry

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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BOC Sciences [email protected] 1-631-504-6093

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Beijing JingSource Pharmaceutical Technology Co., Ltd. [email protected] +86 (10) 5286-5516 China

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Beijing Mediking Biopharm Co., Ltd. [email protected],[email protected] +86 (10) 8176-9521 / 8975-3524 China

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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Brook Chemical Limited [email protected],[email protected]chembrook.com +86 (21) 5276-2796 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD288/200mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Price and Availability: USD59/1mg ()

Guangzhou Greensyn Co., Ltd. [email protected] +86 (20) 3206-8825 China

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Hangzhou Luckysage Sciene and Technology Co., Ltd. [email protected],[email protected] +86 (571) 8819-9336 China

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JACX Chemical Co., Ltd. [email protected] +86 (795) 450-8261 / +86 18970587571 China

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Jinan Dexinjia Bio&Tech Co., Ltd. [email protected],[email protected] +86 (531) 8237-5849 China

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Matrix Scientific [email protected] Orders: 800-733-0244 (US & CAN),All other calls: 803-788-9494 USA

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Price and Availability: USD425/250mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD288/200mg ()
Quality Control & MSDS Files: HNMR LCMS NP-HPLC MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

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Shanghai Ecust Biomedicine Co., Ltd. [email protected] +86 (21) 5482-1359 China

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD288/200mg ()

Spectrum Chemical Mfg. Corp. [email protected] +1 (310) 516-8000 USA

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Price and Availability: USD5451/10g ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .96 Brand: TargetMol

Price and Availability: USD59/5mg () USD172/25mg () USD296/50mg () USD398/100mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Tokyo Chemical Industry Co., Ltd. [email protected] 03-3668-0489 Japan

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Price and Availability: USD176/50mg ()

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Background Information of Tiotropium (Bromide)

Tiotropium Bromide is a muscarinic acetylcholine receptor (mAChR) antagonist that blocks the binding of the acetylcholine ligand and subsequent opening of the ligand-gated ion channel. IC50 value: Target: mAChR Tiotropium Bromide stops signaling between neurons and leads to muscle relaxation.

Solubility of Tiotropium (Bromide)

Solubility Sources
DMSO >75mg/mL MedChemexpress Co., Ltd.

Storage Condition of Tiotropium (Bromide)

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] [NP-HPLC] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target mAChR
Research Area Neurological Disease
Indications Chronic bronchitis Chronic obstructive pulmonary disease

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Tiotropium (Bromide) - Launched
Tiotropium (Bromide) Universidade Federal de Sao Paulo - UNIFESP Chronic bronchitis 2007/11/30 2009/1/31 Phase 4 Clinical
Tiotropium (Bromide) Royal Free and University College Medical School Chronic obstructive pulmonary disease 2002/10/31 2005/12/31 Phase 4 Clinical
Tiotropium (Bromide) NHS Greater Glasgow Chronic obstructive pulmonary disease 2006/6/30 2007/12/31 Phase 4 Clinical
Tiotropium (Bromide) Boehringer Ingelheim Pharmaceuticals Inc Chronic obstructive pulmonary disease 2004/3/31 2007/12/01 Phase 4 Clinical
Tiotropium (Bromide) Boehringer Ingelheim Pharmaceuticals Inc Chronic obstructive pulmonary disease 2007/4/30 Phase 4 Clinical

Chemical Information

M.Wt Formula CAS No. Synonyms
472.42 C19H22BrNO4S2 136310-93-5 (1a,2b,4b,5a,7b)-7-[(Hydroxydi-2-thienylacetyl)oxy]-9,9-dimethyl-3-oxa-9-azoniatricyclo[3.3.1.02,4]nonane bromide; (1R,2R,4S,5S,7s)-7-(2-hydroxy-2,2-di(thiophen-2-yl)acetoxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.02,4]nonan-9-ium bromide

Structure Information of Tiotropium (Bromide)

Smiles OC(C1=CC=CS1)(C(O[[email protected]]2C[[email protected]@]([N+]3(C)C)([H])[[email protected]@H]4O[[email protected]@H]4[[email protected]@]3([H])C2)=O)C5=CC=CS5.[Br-]
InChI InChI=1S/C19H22NO4S2.BrH/c1-20(2)12-9-11(10-13(20)17-16(12)24-17)23-18(21)19(22,14-5-3-7-25-14)15-6-4-8-26-15;/h3-8,11-13,16-17,22H,9-10H2,1-2H3;1H/q+1;/p-1/t11-,12-,13+,16-,17+;

Related Products

Other Form Products of Tiotropium (Bromide)

Name CAS Formula Suppliers
Tiotropium (bromide hydrate) 139404-48-1 C19H24BrNO5S2 14

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Recommended Products in the Same Indication

Name CAS Formula Suppliers
Carvedilol 72956-09-3 C24H26N2O4 22
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Glycopyrrolate 596-51-0 C19H28BrNO3 21
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Formoterol 67346-49-0 C19H24N2O4 7
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Sildenafil 139755-83-2 C22H30N6O4S 19
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1-(1-(Benzo[b]thiophen-2-yl)ethyl)-1-hydroxyurea 111406-87-2 C11H12N2O2S 16
Faropenem daloxate 141702-36-5 C17H19NO8S 9
Salmeterol (xinafoate) 94749-08-3 C36H45NO7 21
Olodaterol 868049-49-4 C21H26N2O5 13
AZD-5069 878385-84-3 C18H22F2N4O5S2 10

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:218-2200C
Boiling point: Flash Point:
Water Solubility: Solubility:DMSO:47.24mg/mL;100mM;water:9.45mg/mL;20mM;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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