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Tofacitinib (citrate)

(CAS: 540737-29-9)

Suppliers of Tofacitinib (citrate)

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AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Price and Availability: USD90/10mg (In stock)

BOC Sciences [email protected] 1-631-504-6093

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Price and Availability: USD145/5mg ()

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD60/10mg () USD96/50mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Chengdu Sino-Strong Pharmaceutical Co., Ltd. [email protected],[email protected] +86 (28) 8278-3659 China

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LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

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Price and Availability: USD52/25mg (In stock) USD75/50mg (In stock) USD123/100mg (In stock) USD183/200mg (In stock) USD397/500mg (In stock) USD596/1g (In stock) USD998/2g (In stock)

Lanzhou Boc Chemical Co., Ltd. [email protected],[email protected] +86 (21) 3497-6665 ex 801 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD60/10mg () USD96/50mg ()
Quality Control & MSDS Files: HNMR LCMS NP-HPLC MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

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Price and Availability: USD60/5mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD147/10mg (In stock) USD191/10mM/1mLIn DMSO (In stock) USD470/50mg (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HPLC HPLC HNMR HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Sigma-Aldrich, Inc. [email protected] +86 (21) 6141-5566 / 800-819-3336 USA

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Suzhou Howsine Biological Technology Co., Ltd. [email protected],[email protected] +86 (512) 6812-8052 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD98/25mg () USD186/50mg () USD268/100mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Price and Availability: USD165/10mg ()

Wuhan Sunrise Technology Development Company Limited [email protected],[email protected] +86 (27) 8331-4682 / +86 13554138826 China

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Background Information of Tofacitinib (citrate)

Tofacitinib citrate (CP-690550 citrate) is a novel inhibitor of JAK3 with IC50 of 1 nM, 20- to 100-fold less potent against JAK2 and JAK1. IC50 value: 1 nM [1] Target: JAK3 in vitro: CP-690550 is a specific, orally inhibitor of JAK3, it is 20- to 100-fold less potent for JAK2 and JAK1 with IC50 of 20 nM and 112 nM, respectively.

Solubility of Tofacitinib (citrate)

Solubility Sources
Soluble in DMSO at 100 mg/mL; very poorly soluble in ethanol; soluble in water at 6 mg/mL with warming; buffers, serum, or other additives may increase or decrease the aqueous solubility. LC Laboratoies
DMSO >50 mg/mL Ethanol >50mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 100 mg/mL warming (198.21 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 0.5% methylcellulose30 mg/mL Selleck Chemicals LLC

Storage Condition of Tofacitinib (citrate)

Storage Condition Sources
Store at or below -20 oC. LC Laboratoies

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] [NP-HPLC] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways JAK/STAT Signaling Epigenetics Stem Cell/Wnt
Target JAK
Research Area Inflammation/Immunology
Indications Rheumatoid arthritis Psoriatic arthritis Psoriasis

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Tofacitinib (citrate) - Launched
Tofacitinib (citrate) Pfizer Inc Rheumatoid arthritis 2013/7/31 2019/7/31 Phase 4 Clinical
Tofacitinib (citrate) Pfizer Inc Psoriatic arthritis 2013/11/30 2019/1/31 Phase 3 Clinical
Tofacitinib (citrate) Pfizer Inc Psoriatic arthritis 2013/7/31 2015/8/31 Phase 3 Clinical
Tofacitinib (citrate) Pfizer Inc Psoriatic arthritis 2013/11/30 2016/2/29 Phase 3 Clinical
Tofacitinib (citrate) Pfizer Inc Psoriasis 2013/11/30 2015/5/31 Phase 3 Clinical

Chemical Information

M.Wt Formula CAS No. Synonyms
504.49 C22H28N6O8 540737-29-9 Tasocitinib citrate;CP-690550 citrate;CP 690550 citrate;CP690550 citrate; 3-((3R,4R)-4-methyl-3-(methyl(7H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)piperidin-1-yl)-3-oxopropanenitrile 2-hydroxypropane-1,2,3-tricarboxylate

Structure Information of Tofacitinib (citrate)

Smiles O=C(CC#N)N1C[[email protected]](N(C2=C3C(NC=C3)=NC=N2)C)[[email protected]](C)CC1.O=C(CC(C(O)=O)(O)CC(O)=O)O
InChI InChI=1S/C16H20N6O.C6H8O7/c1-11-5-8-22(14(23)3-6-17)9-13(11)21(2)16-12-4-7-18-15(12)19-10-20-16;7-3(8)1-6(13,5(11)12)2-4(9)10/h4,7,10-11,13H,3,5,8-9H2,1-2H3,(H,18,19,20);13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/t11-,13+;/m1./s1

Related Products

Other Form Products of Tofacitinib (citrate)

Name CAS Formula Suppliers
(3R,4S)-Tofacitinib 1092578-46-5 C16H20N6O 8
(3S,4S)-Tofacitinib 1092578-47-6 C16H20N6O 8
(3S,4R)-Tofacitinib 1092578-48-7 C16H20N6O 7
Tofacitinib 477600-75-2 C16H20N6O 16

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Sotrastaurin 425637-18-9 C25H22N6O2 14
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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,100 mg/mLwarmed(198.21 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):0.5% methylcelluloseFor best results, use promptly
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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