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Cabazitaxel

(CAS: 183133-96-2)

Suppliers of Cabazitaxel

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand:

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Affix Scientific [email protected] +1-510-936-6647 USA

Fax: Purity: >98% Brand:

Price and Availability: USD899/1g (In stock)
Quality Control & MSDS Files: CoA MSDS

Angelisun (Chongqing) Pharmaceutical Co., Ltd. [email protected] +86 (23) 6803-0926 ex 816 China

Fax: +86 (23) 6803-0915Purity: Brand:

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

Fax: +1 (847) 367-3681Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Price and Availability: USD298/500mg (In stock)

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD72/5mg () USD108/10mg ()

Carbosynth Limited [email protected] +44 (1635) 578-444

Fax: +44 (1635) 579-444Purity: Brand:

Price and Availability: USD132/250mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

Janlon Biopharma Co., Ltd. [email protected] +86 (512) 6790-9115 China

Fax: +86 (512) 6790-9117Purity: Brand:

Jiangsu Yew Pharmaceutical Co., Ltd. [email protected] +86 (510) 6686-5972 China

Fax: +86 (510) 6686-5972Purity: Brand:

LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

Fax: +1-781-938-5420Purity: Brand:

Price and Availability: USD52/5mg (In stock) USD81/10mg (In stock) USD124/25mg (In stock) USD179/50mg (In stock) USD247/100mg (In stock) USD418/200mg (In stock) USD733/500mg (In stock)

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD72/5mg () USD108/10mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Price and Availability: USD75/5mg ()
Quality Control & MSDS Files: CoA HNMR CNMR HPLC LCMS MSDS

Ningbo Tianheng Pharmaceutical Co., Ltd. [email protected] +86 (574) 8669-0026 / 8669-0021 China

Fax: +86 (574) 8669-2706Purity: Brand:

ProbeChem [email protected] 86-21-80183644

Fax: 86-21-68860190Purity: Brand:

Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

Fax: 617-206-9595Purity: Inquiry Brand:

Price and Availability: USD55/20mg (In stock)

Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

Fax: 214-358-6070Purity: Brand:

Price and Availability: USD75/5mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD170/5mg (In stock) USD270/10mg (In stock) USD570/10mM/1mLIn DMSO (In stock) USD718/10mM(in 1mL DMSO) (in 1mL DMSO) USD1870/100mg (In stock) USD2770/200mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD72/5mg () USD108/10mg ()

Shanghai Jinhe Bio-Technology Co., Ltd. [email protected],[email protected] +86 (21) 5981-0660 China

Fax: +86 (21) 5981-0661Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .99 Brand: TargetMol

Price and Availability: USD95/10mg () USD190/25mg () USD256/50mg ()

ZHIYU Biotechnology Co., Ltd. [email protected],[email protected] +86 (512) 6279-1916 / +86 18912796596 China

Fax: +86 (512) 6279-1915Purity: Brand:

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Background Information of Cabazitaxel

Cabazitaxel(XRP6258; RPR-116258A) is a semi-synthetic derivative of the natural taxoid 10-deacetylbaccatin III with potential antineoplastic activity.

Solubility of Cabazitaxel

Solubility Sources
Soluble in DMSO Affix Scientific
Soluble in DMSO at 100 mg/mL; soluble in ethanol at 50 mg/mL; very poorly soluble in water; maximum solubility in plain water is estimated to be about 1-2 μM; buffers, serum, or other additives may increase or decrease the aqueous solubility. LC Laboratoies
DMSO MedChemexpress Co., Ltd.
Soluble in DMSO, not in water MedKoo Biosciences, Inc.
(25°C) * In vitro DMSO 100 mg/mL (119.62 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Cabazitaxel

Storage Condition Sources
Up to one week at 4°C or six months at -20°C. Affix Scientific
Store at or below -20 oC. LC Laboratoies
Storage condition:Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). Stock solution storage:0 - 4 C for short term (days to weeks), or -20 C for long term (months). Shipped under ambient temperature as non-hazardous chemical. This product is stable enough for a few weeks during ordinary shipping and time spent in Customs. MedKoo Biosciences, Inc.

MSDS Information

MSDS Sources
Affix Scientific
MedChemexpress Co., Ltd.
MedKoo Biosciences, Inc.

Quality Control and Spectral Data

QC Reports Sources
[CoA] Affix Scientific
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[CoA] [HNMR] [CNMR] [HPLC] [LCMS] MedKoo Biosciences, Inc.
[HNMR] [HPLC] Selleck Chemicals LLC

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Cabazitaxel Associació per a la Recerca Oncologica Transitional cell carcinoma 2012/10/31 2016/11/30 Phase 3 Clinical
Cabazitaxel University Hospital Birmingham NHS Foundation Trust Transitional cell carcinoma 2013/1/31 2015/12/31 Phase 3 Clinical
Cabazitaxel Krankenhaus Nordwest Metastatic stomach cancer 2013/9/30 Phase 2 Clinical
Cabazitaxel Rheinisch-Westfalische Technische Hochschule Aachen (RWTH) Metastatic prostate cancer 2013/7/31 2018/8/31 Phase 2 Clinical
Cabazitaxel Sarah Cannon Research Institute Metastatic breast cancer 2013/11/30 2016/3/31 Phase 2 Clinical
Cabazitaxel - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
835.93 C45H57NO14 183133-96-2 (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-acetoxy-9-(((2R,3S)-3-((tert-butoxycarbonyl)amino)-2-hydroxy-3-phenylpropanoyl)oxy)-11-hydroxy-4,6-dimethoxy-4a,8,13,13-tetramethyl-5-oxo-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-1H-7,11-methanocyclodeca[3,4]benzo[1,2-b]oxet-12-yl benzoate

Structure Information of Cabazitaxel

Smiles C[[email protected]]1(C([[email protected]@H]2OC)=O)[[email protected]@H]([[email protected]@]3(OC(C)=O)[[email protected]](OC3)C[[email protected]@H]1OC)[[email protected]](OC(c4ccccc4)=O)[[email protected]]5(O)C[[email protected]](OC([[email protected]](O)[[email protected]](c6ccccc6)NC(OC(C)(C)C)=O)=O)C(C)=C2C5(C)C
InChI InChI=1S/C45H57NO14/c1-24-28(57-39(51)33(48)32(26-17-13-11-14-18-26)46-40(52)60-41(3,4)5)22-45(53)37(58-38(50)27-19-15-12-16-20-27)35-43(8,36(49)34(55-10)31(24)42(45,6)7)29(54-9)21-30-44(35,23-56-30)59-25(2)47/h11-20,28-30,32-35,37,48,53H,21-23H2,1-10H3,(H,46,52)/t28-,29-,30+,32-,33+,34+,35-,37-,43+,44-,45+/m0/s1

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Other Form Products of Cabazitaxel

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,100 mg/mL(119.62 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;
Density:1.31 Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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