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Cobimetinib (racemate)

(CAS: 934662-91-6)

Suppliers of Cobimetinib (racemate)

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD216/5mg () USD360/10mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD216/5mg () USD360/10mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

ProbeChem [email protected] 86-21-80183644

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD216/5mg () USD360/10mg ()

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Background Information of Cobimetinib (racemate)

Cobimetinib(GDC-0973; XL518) is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2). IC50 value: Target: MEK1/2 in vitro: The combination of GDC-0973 with the PI3K inhibitor GDC-0941 resulted in combination efficacy in vitro and in vivo via induction of biomarkers associated with apoptosis, including Bcl-2 family proapoptotic regulators [1]. in vivo: The population rate constants associated with tumor growth inhibition for GDC-0973 and GDC-0941 were 0.00102 and 0000651 μM(-1) h(-1), respectively.

Solubility of Cobimetinib (racemate)

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of Cobimetinib (racemate)

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways MAPK/ERK Pathway
Target MEK
Research Area Cancer
Indications Stage IV melanoma Advanced solid tumor

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Cobimetinib (racemate) Roche Holding AG Stage IV melanoma 2013/1/31 2016/11/30 Phase 3 Clinical
Cobimetinib (racemate) Genentech Inc Advanced solid tumor 2013/10/01 2016/3/01 Phase 1 Clinical
Cobimetinib (racemate) Genentech Inc Advanced solid tumor 2012/4/30 2014/8/31 Phase 1 Clinical
Cobimetinib (racemate) Roche Holding AG Stage IV melanoma 2011/2/28 2014/10/31 Phase 1 Clinical
Cobimetinib (racemate) Genentech Inc Advanced solid tumor 2009/11/30 2014/3/31 Phase 1 Clinical
Cobimetinib (racemate) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
531.31 C21H21F3IN3O2 934662-91-6 GDC-0973 racemate;XL-518;GDC 0973;XL 518;GDC0973;XL518; (3,4-difluoro-2-((2-fluoro-4-iodophenyl)amino)phenyl)(3-hydroxy-3-(piperidin-2-yl)azetidin-1-yl)methanone

Structure Information of Cobimetinib (racemate)

Smiles FC1=C(F)C=CC(C(N2CC(C3CCCCN3)(O)C2)=O)=C1NC4=CC=C(I)C=C4F
InChI InChI=1S/C21H21F3IN3O2/c22-14-6-5-13(19(18(14)24)27-16-7-4-12(25)9-15(16)23)20(29)28-10-21(30,11-28)17-3-1-2-8-26-17/h4-7,9,17,26-27,30H,1-3,8,10-11H2

Related Products

Other Form Products of Cobimetinib (racemate)

Name CAS Formula Suppliers
Cobimetinib (R-enantiomer) 934660-94-3 C21H21F3IN3O2 10
Cobimetinib 934660-93-2 C21H21F3IN3O2 14

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MK-0752 471905-41-6 C21H21ClF2O4S 16
ZSTK474 475110-96-4 C19H21F2N7O2 20
BMS-599626 714971-09-2 C27H27FN8O3 14
PHA-848125 802539-81-7 C25H32N8O 15

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:Soluble in DMSO
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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