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Iloperidone

(CAS: 133454-47-4)

Suppliers of Iloperidone

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AOBIOUS INC [email protected] (508) 306-0937 USA

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AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Aladdin [email protected] 400 620 6333 China

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Price and Availability: RMB864/10mg () RMB3333/50mg ()

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Axon Medchem BV [email protected];[email protected] +31 50 3118007 Netherlands

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Beijing Bode United Chemical Co., Ltd. [email protected] +86 13693519000 China

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Beijing Gaobo Pharm-Chemicals Tech. Co., Ltd [email protected] 010-52266256 CHINA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Carbosynth Limited [email protected] +44 (1635) 578-444

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Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Chengdu Sino-Strong Pharmaceutical Co., Ltd. [email protected],[email protected] +86 (28) 8278-3659 China

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Chuzhou Baiao Biotechnology Co., Ltd. [email protected] +86-550-2181681 +86-25-83212599; Mobile:+86-18951809019 China

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Cooper Chemical Co., Ltd. [email protected] +86 18600011762 China

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Langfang Gaobo Jingband Pharmaceutical Co., Ltd. [email protected],[email protected] +86 (10) 8369-4934 / +86 13911386546 China

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Linyi Shengxin Pharmaceutical R&D Co., Ltd. [email protected],[email protected] +86 18653953873 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Quality Control & MSDS Files: LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

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Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

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Price and Availability: USD135/10mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD70/10mg (In stock) USD90/10mM/1mLIn DMSO (In stock) USD270/50mg (In stock) USD470/100mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC

Shanghai DND Pharm-Technology Co., Inc. [email protected],[email protected] +86 (21) 5878-3620 / 5878-3570 ex 8011 China

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD62/10mg () USD240/50mg ()

Taizhou Jiakang Chemical Co., Ltd. [email protected],[email protected] +86 (576) 8822-6722 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .97 Brand: TargetMol

Price and Availability: USD24/2mg () USD68/10mg () USD152/50mg () USD240/100mg ()

Thode Laboratories [email protected] 1-416-8007660 Canada

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Price and Availability: USD120/10mg (In Stock)

Tokyo Chemical Industry Co., Ltd. [email protected] 03-3668-0489 Japan

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Price and Availability: USD37/25mg ()

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Background Information of Iloperidone

Iloperidone(HP 873) is a D2/5-HT2 receptor antagonist, which is an atypical antipsychotic for the treatment of schizophrenia symptoms. IC50 value: Target: 5-HT receptor; D2 receptor Iloperidone (HP 873) is a compound currently in clinical trials for the treatment of schizophrenia.

Solubility of Iloperidone

Solubility Sources
DMSO 27 mg/mL; Water <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 27 mg/mL (63.3 mM); Ethanol4 mg/mL (9.37 mM); Water<1 mg/mL (<1 mM); In vivo 2% DMSO+40% PEG 300+dd H2O1.6mg/mL Selleck Chemicals LLC

Storage Condition of Iloperidone

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Neuronal Signaling GPCR/G Protein
Target Dopamine Receptor 5-HT Receptor
Research Area Neurological Disease
Indications Depression Schizophrenia

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Iloperidone Massachusetts General Hospital Depression 2012/4/30 2014/4/30 Phase 4 Clinical
Iloperidone Novartis AG Schizophrenia 2010/8/31 2011/12/31 Phase 4 Clinical
Iloperidone Novartis AG Schizophrenia 2011/2/28 2018/12/31 Phase 3 Clinical
Iloperidone New York State Psychiatric Institute 2012/11/30 2014/3/31 Phase 4 Clinical
Iloperidone Northwestern University Schizophrenia 2012/4/30 2015/12/31 Phase 4 Clinical
Iloperidone - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
426.48 C24H27FN2O4 133454-47-4 1-[4-[3-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone; 1-(4-(3-(4-(6-fluorobenzo[d]isoxazol-3-yl)piperidin-1-yl)propoxy)-3-methoxyphenyl)ethanone

Structure Information of Iloperidone

Smiles FC1=CC2=C(C=C1)C(C3CCN(CCCOC4=C(OC)C=C(C(C)=O)C=C4)CC3)=NO2
InChI InChI=1S/C24H27FN2O4/c1-16(28)18-4-7-21(23(14-18)29-2)30-13-3-10-27-11-8-17(9-12-27)24-20-6-5-19(25)15-22(20)31-26-24/h4-7,14-15,17H,3,8-13H2,1-2H3

Related Products

Other Form Products of Iloperidone

Name CAS Formula Suppliers
Iloperidone (hydrochloride) 1299470-39-5 C24H28ClFN2O4 7

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Risperidone (mesylate) 666179-96-0 C24H31FN4O5S 7
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Preladenant 377727-87-2 C25H29N9O3 14
Ziprasidone (hydrochloride monohydrate) 138982-67-9 C21H24Cl2N4O2S 19
Ziprasidone D8 1126745-58-1 C21H13D8ClN4OS 9

Safety Data of Iloperidone

Hazard Symbols:F,T Risk Statements:11-23/24/25-39/23/24/25 Safety Statements:16-36/37-45
Transport Information: HS Code: RTECS:
WGK Germany:

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:118-120°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,27 mg/mL(63.3 mM);In vitro:Ethanol,4 mg/mL(9.37 mM);In vitro:Water,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):2% DMSO+40% PEG 300+dd H2OFor best results, use promp
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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