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Leuprolide (Acetate)

(CAS: 74381-53-6)

Suppliers of Leuprolide (Acetate)

Company Name Email Tel Country
AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD84/5mg () USD108/10mg ()

Carbosynth Limited [email protected] +44 (1635) 578-444

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Lancrix Chemicals. [email protected] 86 21 50817262 China

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Price and Availability: USD236/25mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD84/5mg () USD108/10mg ()
Quality Control & MSDS Files: HNMR NP-HPLC MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Tokyo Chemical Industry Co., Ltd. [email protected] 03-3668-0489 Japan

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Xiangfan Goto Chemical Co., Ltd [email protected] +86-710-3423122 3423123 CHINA

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Background Information of Leuprolide (Acetate)

Leuprolide acetate (Leuprorelin) is a GnRH analog; leuprolide acetate acts as an agonist at pituitary GnRH receptors. IC50 Value: Target: GnRH receptor By interrupting the normal pulsatile stimulation of, and thus desensitizing, the GnRH receptors, it indirectly downregulates the secretion of gonadotropins luteinizing hormone (LH) and follicle-stimulating hormone (FSH), leading to hypogonadism and thus a dramatic reduction in estradiol andtestosterone levels in both sexes. in vitro: The number of DNA 3'-end-labeled cells/cm2 in leiomyomas of control patients and in leiomyomas at the 2nd, 8th, 12th, and 16th weeks of Leuprolide Acetate treatment were at low levels [1].

Solubility of Leuprolide (Acetate)

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of Leuprolide (Acetate)

Storage Condition Sources
Up to one week at 4°C or six months at -20°C. Affix Scientific

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[CoA] Affix Scientific
[HNMR] [NP-HPLC] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways GPCR/G Protein
Target GNRH Receptor
Research Area Endocrinology
Indications Prostate tumor Metastatic prostate cancer Hormone dependent prostate cancer

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Leuprolide (Acetate) Ipsen Prostate tumor 2012/8/31 2014/9/30 Phase 4 Clinical
Leuprolide (Acetate) HanAll Biopharma Co Ltd Metastatic prostate cancer 2011/1/31 2013/12/31 Phase 4 Clinical
Leuprolide (Acetate) Abbott Laboratories Prostate tumor 2011/6/30 2017/5/31 Phase 4 Clinical
Leuprolide (Acetate) Actavis Inc Hormone dependent prostate cancer 2010/7/31 2011/4/30 Phase 4 Clinical
Leuprolide (Acetate) Chesapeake Urology Research Associates Prostate tumor 2003/10/31 2009/6/30 Phase 4 Clinical
Leuprolide (Acetate) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
1269.45 C61H88N16O14 74381-53-6 Leuprorelin acetate;Lupron; (S)-1-((3S,6S,9S,12S,15R,18S,21S)-3-((1H-imidazol-5-yl)methyl)-6-((1H-indol-3-yl)methyl)-15,18-di-tert-butyl-21-(3-guanidinopropyl)-12-(4-hydroxybenzyl)-9-(hydroxymethyl)-1,4,7,10,13,16,19-heptaoxo-1-((S)-5-oxopyrrolidin-2-yl)-2,5,8,11,14,17,20-heptaazadocosan-22-oyl)-N-ethylpyrrolidine-2-carboxamide acetate

Structure Information of Leuprolide (Acetate)

Smiles O=C(N[[email protected]](C(N[[email protected]@H](CC1=CC=C(O)C=C1)C(N[[email protected]](C(C)(C)C)C(N[[email protected]@H](C(C)(C)C)C(N[[email protected]@H](CCCNC(N)=N)C(N2CCC[[email protected]]2C(NCC)=O)=O)=O)=O)=O)=O)CO)[[email protected]@H](NC([[email protected]](CC3=CN=CN3)NC([[email protected]]4NC(CC4)=O)=O)=O)CC5=CNC6=CC=CC=C65.CC(O)=O
InChI InChI=1S/C59H84N16O12.C2H4O2/c1-8-63-53(84)44-16-12-24-75(44)56(87)39(15-11-23-64-57(60)61)68-54(85)46(58(2,3)4)74-55(86)47(59(5,6)7)73-51(82)40(25-32-17-19-35(77)20-18-32)69-52(83)43(30-76)72-49(80)41(26-33-28-65-37-14-10-9-13-36(33)37)70-50(81)42(27-34-29-62-31-66-34)71-48(79)38-21-22-45(78)67-38;1-2(3)4/h9-10,13-14,17-20,28-29,31,38-44,46-47,65,76-77H,8,11-12,15-16,21-27,30H2,1-7H3,(H,62,66)(H,63,84)(H,67,78)(H,68,85)(H,69,83)(H,70,81)(H,71,79)(H,72,80)(H,73,82)(H,74,86)(H4,60,61,64);1H3,(H,3,4)/t38-,39-,40-,41-,42-,43-,44-,46+,47-;/m0./s1

Related Products

Other Form Products of Leuprolide (Acetate)

Name CAS Formula Suppliers

Recommended Products in Same Target

Name CAS Formula Suppliers
Goserelin Acetate 65807-02-5 C59H79D5N18O14 12
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Alarelin (Acetate) 79561-22-1 C60H86N16O16 16
Relugolix 737789-87-6 C29H27F2N7O5S 8
Elagolix 834153-87-6 C32H30F5N3O5 11
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Nafarelin 76932-56-4 C66H83N17O13 9
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Gonadorelin 33515-09-2 C55H75N17O13 6
Cetrorelix (Acetate) 145672-81-7 C72H96ClN17O16 6
Buserelin (Acetate) 68630-75-1 C64H93N15O15 4
Deslorelin 57773-65-6 C64H83N17O12 8
Gonadorelin (acetate) 34973-08-5 C57H79N17O15 8
Leuprorelin 53714-56-0 C59H84N16O12 11
Triptorelin 57773-63-4 C64H82N18O13 8
Goserelin (acetate) 145781-92-6 C61H88N18O16 10
Leuprolide Acetate 74381-53-6 C61H88N16O14 5
Alarelin (Acetate) 79561-22-1 C60H86N16O16 7
Buserelin (Acetate) 68630-75-1 C62H90N16O15 5

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Safety Data of Leuprolide (Acetate)

Hazard Symbols: Risk Statements: Safety Statements:22-24/25
Transport Information: HS Code: RTECS:OH6390000
WGK Germany:2

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:150-155°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,100 mg/mL(78.77 mM);In vitro:Water,100 mg/mL(78.77 mM);In vitro:Ethanol,100 mg/mL(78.77 mM);
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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