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RG7388

(CAS: 1229705-06-9)

Suppliers of RG7388

Company Name Email Tel Country
AOBIOUS INC [email protected] (508) 306-0937 USA

Fax: Purity: Brand:

Price and Availability: USD30/1mg ()

AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Price and Availability: USD150/5mg ()

Aladdin [email protected] 400 620 6333 China

Fax: 021 5102 6000Purity: Brand:

Price and Availability: RMB1449/5mg () RMB5649/50mg ()

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

Fax: +1-832-641-3177Purity: Brand:

Price and Availability: USD187/5mg (In stock)

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Price and Availability: USD455/5mg ()

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 98% Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD144/5mg () USD204/10mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD144/5mg () USD204/10mg ()
Quality Control & MSDS Files: HNMR LCMS NP-HPLC MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD144/5mg () USD204/10mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD85/2mg () USD115/5mg () USD168/10mg () USD308/25mg () USD458/50mg ()

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Background Information of RG7388

RG7388 is an oral, selective, small molecule MDM2 antagonist that inhibits binding of MDM2 to p53.

Solubility of RG7388

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of RG7388

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] [NP-HPLC] MedChemexpress Co., Ltd.

Mechanism and Indications

Signaling Pathways Apoptosis
Target MDM-2/p53
Research Area Cancer
Indications Acute myelogenous leukemia Solid tumor Neoplasm

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
RG7388 Roche Holding AG Acute myelogenous leukemia 2013/2/28 2015/3/31 Phase 1 Clinical
RG7388 Roche Holding AG Solid tumor 2013/8/31 2013/11/30 Phase 1 Clinical
RG7388 Roche Holding AG Neoplasm 2011/11/30 2013/11/30 Phase 1 Clinical
RG7388 - Phase 3

Chemical Information

M.Wt Formula CAS No. Synonyms
616.48 C31H29Cl2F2N3O4 1229705-06-9 RG 7388;RG-7388; 4-((2R,3S,4R,5S)-3-(3-chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxamido)-3-methoxybenzoic acid

Structure Information of RG7388

Smiles O=C(O)C1=CC(OC)=C(NC([[email protected]]2[[email protected]](C3=C(F)C(Cl)=CC=C3)[[email protected]](C4=CC=C(Cl)C=C4F)(C#N)[[email protected]](CC(C)(C)C)N2)=O)C=C1
InChI InChI=1S/C31H29Cl2F2N3O4/c1-30(2,3)14-24-31(15-36,19-10-9-17(32)13-21(19)34)25(18-6-5-7-20(33)26(18)35)27(38-24)28(39)37-22-11-8-16(29(40)41)12-23(22)42-4/h5-13,24-25,27,38H,14H2,1-4H3,(H,37,39)(H,40,41)/t24-,25-,27+,31?/m0/s1

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Name CAS Formula Suppliers
AZD1152 722543-31-9 C26H31FN7O6P 11
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BMS-599626 (Hydrochloride) 873837-23-1 C27H28ClFN8O3 12
AT9283 896466-04-9 C19H23N7O2 21
KX2-391 897016-82-9 C26H29N3O3 14
MLN4924 905579-51-3 C21H25N5O4S 16
SNX-2112 908112-43-6 C23H27F3N4O3 12
Nordihydroguaiaretic acid 500-38-9 C18H22O4 17
Pazopanib (Hydrochloride) 635702-64-6 C21H24ClN7O2S 19
RX-3117 865838-26-2 C10H12FN3O4 8
Crenolanib 670220-88-9 C26H29N5O2 16
OSU-03012 742112-33-0 C26H19F3N4O 12
Motesanib (Diphosphate) 857876-30-3 C22H29N5O9P2 20
LY2603618 911222-45-2 C18H22BrN5O3 15
AT13387 912999-49-6 C24H31N3O3 19
ARRY-520 (R enantiomer) 885060-08-2 C20H22F2N4O2S 8
ARRY-520 885060-09-3 C20H22F2N4O2S 14

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,100 mg/mL(162.21 mM);In vitro:Ethanol,8 mg/mLwarmed(12.97 mM);In vitro:Water,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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