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NVP-BGJ398 (phosphate)

(CAS: 1310746-10-1)

Suppliers of NVP-BGJ398 (phosphate)

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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Axon Medchem BV [email protected];[email protected] +31 50 3118007 Netherlands

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BOC Sciences [email protected] 1-631-504-6093

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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LC Laboratoies [email protected] +1-781-937-0777 +1-800-937-3720 in US and Canada only USA

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Price and Availability: USD49/5mg (In stock) USD74/10mg (In stock) USD98/25mg (In stock) USD148/50mg (In stock) USD244/100mg (In stock) USD431/200mg (In stock) USD725/500mg (In stock) USD1290/1g (In stock)

MedChemexpress Co., Ltd. sale[email protected] 609-228-6898 USA

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Price and Availability: USD72/5mg () USD108/10mg ()
Quality Control & MSDS Files: MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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ProbeChem [email protected] 86-21-80183644

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD72/5mg () USD108/10mg ()

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Background Information of NVP-BGJ398 (phosphate)

NVP-BGJ398 phosphate (BGJ-398) is a novel selective, pan-specific FGFR inhibitor with IC50 of 0.9, 1.4, and 1 nM for FGFR1, FGFR2, and FGFR3, respectively; >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. IC50 Value: 0.9 nM (FGFR1); 1.4 nM (FGFR2); 1 nM (FGFR2) [1] Target: FGFR1/2/3 in vitro: NVP-BGJ398 is a novel and selective fibroblast growth factor receptor (FGFR) inhibitor.

Solubility of NVP-BGJ398 (phosphate)

Solubility Sources
DMSO MedChemexpress Co., Ltd.

Storage Condition of NVP-BGJ398 (phosphate)

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources

Mechanism and Indications

Signaling Pathways Protein Tyrosine Kinase/RTK
Target FGFR
Research Area Cancer
Indications Glioblastoma Stage IV melanoma Advanced solid tumor

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
NVP-BGJ398 (phosphate) Novartis AG Glioblastoma 2013/11/30 2016/5/31 Phase 2 Clinical
NVP-BGJ398 (phosphate) Novartis AG Stage IV melanoma 2013/9/30 2016/10/31 Phase 2 Clinical
NVP-BGJ398 (phosphate) Novartis AG Advanced solid tumor 2013/10/31 2016/3/31 Phase 1 Clinical
NVP-BGJ398 (phosphate) Novartis AG Advanced solid tumor 2012/10/31 2016/3/31 Phase 1 Clinical
NVP-BGJ398 (phosphate) Novartis AG Advanced solid tumor 2009/12/31 2013/12/31 Phase 1 Clinical
NVP-BGJ398 (phosphate) - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
658.47 C26H34Cl2N7O7P 1310746-10-1 BGJ-398 phosphate; BGJ 398 phosphate; NVP BGJ398 phosphate; 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-ethylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)-1-methylurea phosphate

Structure Information of NVP-BGJ398 (phosphate)

Smiles O=P(O)(O)O.ClC1=C(C(Cl)=C(C=C1OC)OC)NC(N(C2=CC(NC3=CC=C(C=C3)N4CCN(CC4)CC)=NC=N2)C)=O
InChI InChI=1S/C26H31Cl2N7O3.H3O4P/c1-5-34-10-12-35(13-11-34)18-8-6-17(7-9-18)31-21-15-22(30-16-29-21)33(2)26(36)32-25-23(27)19(37-3)14-20(38-4)24(25)28;1-5(2,3)4/h6-9,14-16H,5,10-13H2,1-4H3,(H,32,36)(H,29,30,31);(H3,1,2,3,4)

Related Products

Other Form Products of NVP-BGJ398 (phosphate)

Name CAS Formula Suppliers
NVP-BGJ398 872511-34-7 C26H31Cl2N7O3 20

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PHA-848125 802539-81-7 C25H32N8O 15

Chemical and Physical Properties

Appearance:white to gray solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:≥95.7mg/ml in DMSO
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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