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Pimobendan

(CAS: 74150-27-9)

Suppliers of Pimobendan

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Alfa Chemistry [email protected] 1-201-478-8534 USA

Fax: 1-516-927-0118Purity: 0.96 Brand: Alfa Chemistry

Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Apichem Chemical Technology Co., Ltd. [email protected],[email protected] +86 (21) 6199-2249 China

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

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BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD163/5mg () USD307/10mg ()

Guangzhou Topwork Chemical Co., Ltd. [email protected],[email protected] +86 (20) 8731-7062 / +86 13544492387 China

Fax: +86 (20) 8731-7061Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD163/5mg () USD307/10mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

Fax: 617-206-9595Purity: 98% Brand:

Price and Availability: USD33/5mg (In stock)

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD170/5mg (In stock) USD230/10mM/1mLIn DMSO (In stock) USD320/10mg (In stock) USD970/50mg (In stock) USD2470/200mg (In stock)
Quality Control & MSDS Files: HPLC HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD163/5mg () USD307/10mg ()

TCS Industry Limited [email protected] +86 (512) 5022-6427 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD114/10mg () USD198/50mg ()

Yitai Pharmatech Co., Ltd. [email protected] +86 (10) 6780-6114 / +86 13811836936 China

Fax: +86 (10) 6780-6115Purity: Brand:

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Background Information of Pimobendan

Pimobendan is a selective inhibitor of PDE3 with IC50 of 0.32 μM. Target: PDE3 Pimobendan exhibits selective inhibition of PDE III isolated from guinea pig cardiac muscle with IC50 of 0.32 uM compared to the inhibition of PDE I and PDE II (IC50s >30 μM).

Solubility of Pimobendan

Solubility Sources
DMSO 67 mg/mL (200 mM); Water <1 mg/mL (<1 mM) MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 67 mg/mL (200.37 mM); Ethanol5 mg/mL (14.95 mM); Water<1 mg/mL (<1 mM); In vivo 0.5% methylcellulose30 mg/mL Selleck Chemicals LLC

Storage Condition of Pimobendan

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Metabolic Enzyme/Protease
Target Phosphodiesterase (PDE)
Research Area Cardiovascular Disease
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Pimobendan - Launched
Pimobendan - No Development Reported

Chemical Information

M.Wt Formula CAS No. Synonyms
334.37 C19H18N4O2 74150-27-9 Vetmedin;Acardi;pimobendane; 6-(2-(4-methoxyphenyl)-1H-benzo[d]imidazol-6-yl)-5-methyl-4,5-dihydropyridazin-3(2H)-one

Structure Information of Pimobendan

Smiles O=C1CC(C)C(C2=CC=C3N=C(C4=CC=C(OC)C=C4)NC3=C2)=NN1
InChI InChI=1S/C19H18N4O2/c1-11-9-17(24)22-23-18(11)13-5-8-15-16(10-13)21-19(20-15)12-3-6-14(25-2)7-4-12/h3-8,10-11H,9H2,1-2H3,(H,20,21)(H,22,24)

Related Products

Other Form Products of Pimobendan

Name CAS Formula Suppliers
Pimobendan (hydrochloride) 77469-98-8 C19H19ClN4O2 6

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,67 mg/mL(200.37 mM);In vitro:Ethanol,5 mg/mL(14.95 mM);In vitro:Water,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):0.5% methylcelluloseFor best results, use promptly
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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