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(CAS: 1744-22-5)

Suppliers of Riluzole

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AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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BOC Sciences [email protected] 1-631-504-6093

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Beijing Dezhong Wanquan Medicines Technological Development Co., Ltd. [email protected] +86 (10) 8850-0088 ex 206 China

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD50/50mg () USD72/100mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD50/50mg () USD72/100mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD97/50mg (In stock) USD130/10mM/1mLIn DMSO (In stock)

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD20/2mg () USD74/10mg () USD156/50mg () USD214/200mg ()

Xuzhou Bestenchem Technology Co., Ltd [email protected] 13705205500 13952161236 CHINA

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Background Information of Riluzole

Riluzole is a glutamate antagonist used as an anticonvulsant and to prolong the survival of patients with amyotrophic lateral sclerosis. Target: Sodium Channel Riluzole inhibits the release of glutamic acid from cultured neurons, and from brain slices.

Solubility of Riluzole

Solubility Sources
DMSO 45 mg/m; Water <1 mg/mL; Ethanol 45 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 47 mg/mL (200.68 mM); Ethanol47 mg/mL (200.68 mM); Water<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Riluzole

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Membrane Transporter/Ion Channel
Target Sodium Channel
Research Area Neurological Disease

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Riluzole - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
234.2 C8H5F3N2OS 1744-22-5 2-Amino-6-(trifluoromethoxy)benzothiazole; 6-Trifluoromethoxy-2-aminobenzothiazole; 6-(Trifluoromethoxy)-1,3-benzothiazol-2-amine; 6-(trifluoromethoxy)benzo[d]thiazol-2-amine

Structure Information of Riluzole

Smiles FC(F)(F)OC1=CC(SC(N)=N2)=C2C=C1
InChI InChI=1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)

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Other Form Products of Riluzole

Name CAS Formula Suppliers
Riluzole hydrochloride 850608-87-6 C8H6ClF3N2OS 5

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Safety Data of Riluzole

Hazard Symbols:T Risk Statements:R25 Safety Statements:S45
Transport Information:UN 2811 HS Code: RTECS:DL2830000
WGK Germany:3

Chemical and Physical Properties

Appearance:Light yellow to yellow Solid Melting point:116-118°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,46 mg/mL(196.41 mM);In vitro:Ethanol,46 mg/mL(196.41 mM);In vitro:Water,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:


[1].Doble, A., The pharmacology and mechanism of action of riluzole. Neurology, 1996. 47(6 Suppl 4): p. S233-41.
The excitotoxic hypothesis of neurodegeneration has stimulated much interest in the possibility of using compounds that will block excitotoxic processes to treat neurologic disorders. Riluzole is a neuroprotective drug that blocks glutamatergic neurotransmission in the CNS. Riluzole inhibits the release of glutamic acid from cultured neurons, from brain slices, and from corticostriatal neurons in vivo. It is thought these effects may be partly due to inactivation of voltage-dependent sodium channels on glutamatergic nerve terminals, as well as activation of a G-protein-dependent signal transduction process. Riluzole also blocks some of the postsynaptic effects of glutamic acid by noncompetitive blockade of N-methyl-D-aspartate (NMDA) receptors. In vivo, riluzole has neuroprotective, anticonvulsant, and sedative properties. In a rodent model of transient global cerebral ischemia, a complete suppression of the ischemia-evoked surge in glutamic acid release has been observed. In vitro, riluzole protects cultured neurons from anoxic damage, from the toxic effects of glutamic-acid-uptake inhibitors, and from the toxic factor in the CSF of patients with amyotrophic lateral sclerosis.

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