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Conivaptan (hydrochloride)

(CAS: 168626-94-6)

Suppliers of Conivaptan (hydrochloride)

Company Name Email Tel Country
Abblis Chemicals LLC [email protected] Toll Free: 1-877-799-4928 (US and Canada only) Tel:+1-877-799-4928 USA

Fax: Fax:+1-713-664-0347Purity: Brand:

Price and Availability: USD240/50mg (Out of Stock)

AnHui HaiKang Pharmaceutical Co., Ltd. [email protected],[email protected] +86 (579) 8764-5148 / +86 13335996519 China

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD96/10mg () USD288/50mg ()

Carbosynth Limited [email protected] +44 (1635) 578-444

Fax: +44 (1635) 579-444Purity: Brand:

Price and Availability: USD84/100mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Changzhou Hi-tech Chemicals Ltd. [email protected] +86 (519) 8661-7710 China

Fax: +86 (519) 8662-9007Purity: Brand:

Chico Pharmaceutical Co., Ltd. (Nanjing) [email protected],[email protected] +86 (25) 8435-1604 / +86 13585175604 China

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Clearsynth Labs Limited [email protected] Worldwide Helpline No. +1-415-685-4395; US & Canada (Toll-free) : +1-800-650-8239; Europe : +44-20-3286-0885; India : +91-22-26355700 India

Fax: Purity: Brand:

Price and Availability: USD100/25mg ()

Matrix Scientific [email protected] Orders: 800-733-0244 (US & CAN),All other calls: 803-788-9494 USA

Fax: Orders: 800-580-6330 (US & CAN), All other faxes: 803-788-9419Purity: Brand:

Price and Availability: USD515/250mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD96/10mg () USD288/50mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

ProbeChem [email protected] 86-21-80183644

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Santa Cruz Biotechnology, Inc. [email protected] Toll Free: 800-457-3801 Phone: 214-902-3900 USA

Fax: 214-358-6070Purity: Brand:

Price and Availability: USD240/25mg ()

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD110/10mg (In stock) USD140/10mM/1mLIn DMSO (In stock) USD176/10mM(in 1mL DMSO) (in 1mL DMSO) USD770/100mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD96/10mg () USD288/50mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD73/10mg () USD237/100mg ()

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Background Information of Conivaptan (hydrochloride)

Conivaptan(YM 087) is a non-peptide inhibitor of antidiuretic hormone (vasopressin receptor antagonist) with Ki values of 0.48 and 3.04 nM for rat liver V1A receptor and rat kidney V2 receptor respectively. IC50 value: 0.48 nM (Rat liver V1A receptor); 3.04 nM (Rat kidney V2 receptor) [1] in vitro: YM087 showed high affinity for V1A receptors from rat liver and V2 receptors from rat kidney with Ki values of 0.48 and 3.04 nM, respectively.

Solubility of Conivaptan (hydrochloride)

Solubility Sources
DMSO 107 mg/ml; Water <1 mg/ml MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 107 mg/mL (199.98 mM); Ethanol7 mg/mL (13.08 mM); Water<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Conivaptan (hydrochloride)

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways GPCR/G Protein
Target Vasopressin Receptor
Research Area Cardiovascular Disease
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Conivaptan (hydrochloride) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
535.04 C32H27ClN4O2 168626-94-6 N-[4-(2-Methyl-4,5-dihydro-3H-imidazo[4,5-d][1]benzazepine-6-carbonyl)phenyl]-2-phenylbenzamide hydrochloride; N-(4-(2-methyl-1,4,5,6-tetrahydrobenzo[b]imidazo[4,5-d]azepine-6-carbonyl)phenyl)-[1,1'-biphenyl]-2-carboxamide hydrochloride

Structure Information of Conivaptan (hydrochloride)

Smiles O=C(C1=CC=C(NC(C(C=CC=C2)=C2C3=CC=CC=C3)=O)C=C1)N4C5=CC=CC=C5C(NC(C)=N6)=C6CC4.Cl
InChI InChI=1S/C32H26N4O2.ClH/c1-21-33-28-19-20-36(29-14-8-7-13-27(29)30(28)34-21)32(38)23-15-17-24(18-16-23)35-31(37)26-12-6-5-11-25(26)22-9-3-2-4-10-22;/h2-18H,19-20H2,1H3,(H,33,34)(H,35,37);1H

Related Products

Other Form Products of Conivaptan (hydrochloride)

Name CAS Formula Suppliers
Conivaptan 210101-16-9 C32H26N4O2 7

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Tolvaptan 150683-30-0 C26H25ClN2O3 16
WAY-151932 220460-92-4 C23H19ClN4O 4
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Tolvaptan 150683-30-0 C26H25ClN2O3 11

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,107 mg/mL(199.98 mM);In vitro:Ethanol,7 mg/mL(13.08 mM);In vitro:Water,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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