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Eplerenone

(CAS: 107724-20-9)

Suppliers of Eplerenone

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AA Blocks LLC [email protected] +1 858-523-8231

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AOBIOUS INC [email protected] (508) 306-0937 USA

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Airsea(Taizhou) Pharmaceutical Co., Ltd [email protected] +86-576-8057622, 8698002 CHINA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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Astatech, Inc. [email protected] +1 (215) 785-3197 USA

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BLD Pharmatech [email protected] +86-21-61629022

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BOC Sciences [email protected] 1-631-504-6093

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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Biosyn Healthy Pharma Co., Ltd. [email protected] +86 (22) 8386-5698 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD80/10mg () USD235/50mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Hangzhou Hysen Pharma Co., Ltd. [email protected] +86 (571) 8829-8691 China

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Heta Pharm & Chem Co., Ltd. [email protected],[email protected] +86 (571) 8829-8691 China

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Jiangxi Hongyuan Pharmaceutical Raw Material Co., Ltd. [email protected] +86 (571) 8715-7521 China

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Jiangxi Yuneng Pharmchem Co., Ltd. [email protected] +86 (796) 840-2708 / +86 13307063230 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD80/10mg () USD235/50mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Rota Pharm & Chem Co., Ltd. [email protected] +86 (571) 8836-9502 China

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD97/10mg (In stock) USD170/25mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Price and Availability: USD80/10mg () USD235/50mg ()

Taizhou Yojoy Chemical Co., Ltd. [email protected] +86 (576) 8783-1166 / +86 18605861109 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD36/2mg () USD125/10mg () USD201/25mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Utopharm Co., Ltd. [email protected],[email protected] +86 (21) 5409-1930 / +86 13818182692 China

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Zhejiang Wonderful Pharma & Chem Co., Ltd. [email protected] +86 (576) 8829-0708 China

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Background Information of Eplerenone

Eplerenone is an aldosterone antagonist with an IC50 of 0.36 μM. Target: Mineralocorticoid Receptor Eplerenone is a selective mineralocorticoid receptor antagonist, which has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion.

Solubility of Eplerenone

Solubility Sources
DMSO <1 mg/mL; Water <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO <1 mg/mL (<1 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) Selleck Chemicals LLC
Soluble to 10 mM in DMSO Tocris Bioscience Inc.

Storage Condition of Eplerenone

Storage Condition Sources
Store at RT Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Metabolic Enzyme/Protease
Target Mineralocorticoid Receptor
Research Area Cardiovascular Disease
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Eplerenone - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
414.49 C24H30O6 107724-20-9 Inspra;Epoxymexrenone; (2'R,4aS,4bR,5aR,6aS,9aS,9bR,10R)-methyl 4a,6a-dimethyl-2,5'-dioxo-3,4,4a,4',5a,5',6,6a,8,9,9a,9b,10,11-tetradecahydro-2H,3'H-spiro[cyclopenta[1,2]phenanthro[4,4a-b]oxirene-7,2'-furan]-10-carboxylate

Structure Information of Eplerenone

Smiles O=C(CC1)O[[email protected]@]21CC[[email protected]@]3([H])[[email protected]]4([H])[[email protected]](C(OC)=O)CC5=CC(CC[[email protected]]5(C)[[email protected]@]46[[email protected]](O6)C[[email protected]@]32C)=O
InChI InChI=1S/C24H30O6/c1-21-7-4-14(25)10-13(21)11-15(20(27)28-3)19-16-5-8-23(9-6-18(26)30-23)22(16,2)12-17-24(19,21)29-17/h10,15-17,19H,4-9,11-12H2,1-3H3/t15-,16+,17-,19+,21+,22+,23-,24-/m1/s1

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:241-243°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,4 mg/mLwarmed(9.65 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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