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Clemastine (fumarate)

(CAS: 14976-57-9)

Suppliers of Clemastine (fumarate)

Company Name Email Tel Country
AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD60/100mg () USD96/200mg ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

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Jinan Chuancheng Pharmaceutical Co., Ltd. [email protected] +86 (531) 8890-2485 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/100mg () USD96/200mg ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Pure Chemistry Scientific Inc. [email protected] 857-928-2050 / 857-366-6788 USA

Fax: 617-206-9595Purity: 90% Brand:

Price and Availability: USD18/1g (In stock)

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD97/50mg (In stock) USD130/10mM/1mLIn DMSO (In stock)
Quality Control & MSDS Files: HPLC HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/100mg () USD96/200mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .95 Brand: TargetMol

Price and Availability: USD20/2mg () USD86/10mg () USD156/50mg () USD254/100mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Wuhan Fortuna Chemical Co., Ltd. [email protected] +86 (27) 5150-5023 China

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Background Information of Clemastine (fumarate)

Clemastine Fumarate is a selective histamine H1 receptor antagonist with IC50 of 3 nM. Target: Histamine H1 Receptor Clemastine Fumarate inhibits histamine induced rise in [Ca2+]i in HL-60 cells with an IC50 of 3 nM as compared with that of chlorpheniramine or diphenhydramine with IC50 values of 20 nM and 100 nM, respectively [1].

Solubility of Clemastine (fumarate)

Solubility Sources
DMSO 35 mg/mL; Water <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 35 mg/mL warming (76.09 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% Propylene glycol, 5% Tween 80, 65% D5W5 mg/mL Selleck Chemicals LLC
Soluble to 50 mM in DMSO Tocris Bioscience Inc.

Storage Condition of Clemastine (fumarate)

Storage Condition Sources
Store at RT Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HPLC] [HNMR] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Immunology/Inflammation Autophagy GPCR/G Protein
Target Histamine Receptor Autophagy
Research Area Neurological Disease

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Clemastine (fumarate) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
459.96 C25H30ClNO5 14976-57-9 (2R)-2-[2-[(1R)-1-(4-Chlorophenyl)-1-phenylethoxy]ethyl]-1-methylpyrrolidine but-2-enedioic acid; (R)-2-(2-((R)-1-(4-chlorophenyl)-1-phenylethoxy)ethyl)-1-methylpyrrolidine fumarate

Structure Information of Clemastine (fumarate)

Smiles C[[email protected]](C1=CC=CC=C1)(OCC[[email protected]@H]2N(C)CCC2)C3=CC=C(Cl)C=C3.OC(/C=C/C(O)=O)=O
InChI InChI=1S/C21H26ClNO.C4H4O4/c1-21(17-7-4-3-5-8-17,18-10-12-19(22)13-11-18)24-16-14-20-9-6-15-23(20)2;5-3(6)1-2-4(7)8/h3-5,7-8,10-13,20H,6,9,14-16H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+/t20-,21-;/m1./s1

Related Products

Other Form Products of Clemastine (fumarate)

Name CAS Formula Suppliers
Clemastine 15686-51-8 C21H26ClNO 3

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Chemical and Physical Properties

Appearance:Light yellow to yellow Liquid Melting point:158-162°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,35 mg/mLwarmed(76.09 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):30% propylene glycol, 5% Tween 80, 65% D5WFor best re
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:239-055-2
Optical Rotation: alpha:

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