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Irsogladine

(CAS: 57381-26-7)

Suppliers of Irsogladine

Company Name Email Tel Country
AA Blocks LLC [email protected] +1 858-523-8231

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AbMole BioScience [email protected] 1-800-660-8580 USA

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AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BLD Pharmatech [email protected] +86-21-61629022

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD66/100mg () USD180/500mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD66/100mg () USD180/500mg ()
Quality Control & MSDS Files: LCMS HNMR MSDS

Nanjing Boerkai Chemical Co., Ltd [email protected] +86-25-51792162 13002529772 CHINA

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD97/50mg (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD66/100mg () USD180/500mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD52/100mg ()

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Background Information of Irsogladine

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. Target: PDE4; mACHR Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively.

Solubility of Irsogladine

Solubility Sources
DMSO 2 mg/mL; Water <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 2 mg/mL (7.8 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Irsogladine

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[LCMS] [HNMR] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
Target Phosphodiesterase (PDE) mAChR
Research Area Inflammation/Immunology
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Irsogladine - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
256.09 C9H7Cl2N5 57381-26-7 Dicloguamine; 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine

Structure Information of Irsogladine

Smiles NC1=NC(N)=NC(C2=CC(Cl)=CC=C2Cl)=N1
InChI InChI=1S/C9H7Cl2N5/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7/h1-3H,(H4,12,13,14,15,16)

Related Products

Other Form Products of Irsogladine

Name CAS Formula Suppliers
Irsogladine (maleate) 84504-69-8 C13H11Cl2N5O4 14

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Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:268-269°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,2 mg/mL(7.8 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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