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Irsogladine (maleate)

(CAS: 84504-69-8)

Suppliers of Irsogladine (maleate)

Company Name Email Tel Country
Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

BioVision, Inc., [email protected] 408-493-1800 Toll Free: 800-891-9699 (US Only) USA

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

Bokai Chemical Co., Ltd [email protected] 0519—83565200/83565300 CHINA

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CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD66/100mg () USD180/500mg ()

Heta Pharm & Chem Co., Ltd. [email protected],[email protected] +86 (571) 8829-8691 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD66/100mg () USD180/500mg ()

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD66/100mg () USD180/500mg ()

Suzhou Unite Pharmtech Co., Ltd. [email protected],[email protected] +86 (512) 8766-6020 / +86 13222993784 China

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Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

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Xinxiang Wanfang Chemical Co., Ltd. [email protected] +86 (373) 505-0795 / 232-1813 China

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Zhejiang Wonderful Pharma & Chem Co., Ltd. [email protected] +86 (576) 8829-0708 China

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Background Information of Irsogladine (maleate)

Irsogladine is a PDE4 inhibitor and muscarinic acetylcholine receptor binder. Target: PDE4; mACHR Irsogladine treatment (300 and 500 mg/kg/day) resulted in a dose-dependent reduction of angiogenesis in wild-type mice by 21 and 45.3% (P < 0.02, P < 0.001), in tPA-deficient mice by 42.6 and 46% (P < 0.001, P < 0.001), and in uPA-deficient mice by 27.2 and 46% (P < 0.05, p < 0.001), respectively.

Solubility of Irsogladine (maleate)

Solubility Sources
DMSO MedChemexpress Co., Ltd.
Soluble to 100 mM in DMSO and to 100 mM in ethanol Tocris Bioscience Inc.

Storage Condition of Irsogladine (maleate)

Storage Condition Sources
Desiccate at RT Tocris Bioscience Inc.

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources

Mechanism and Indications

Signaling Pathways Metabolic Enzyme/Protease Neuronal Signaling GPCR/G Protein
Target Phosphodiesterase (PDE) mAChR
Research Area Inflammation/Immunology
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Irsogladine (maleate) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
372.16 C13H11Cl2N5O4 84504-69-8 2,4-Diamino-6-(2,5-dichlorophenyl)-1,3,5-triazine maleate; 6-(2,5-dichlorophenyl)-1,3,5-triazine-2,4-diamine maleate

Structure Information of Irsogladine (maleate)

Smiles ClC1=CC=C(Cl)C(C2=NC(N)=NC(N)=N2)=C1.O=C(O)/C=CC(O)=O
InChI InChI=1S/C9H7Cl2N5.C4H4O4/c10-4-1-2-6(11)5(3-4)7-14-8(12)16-9(13)15-7;5-3(6)1-2-4(7)8/h1-3H,(H4,12,13,14,15,16);1-2H,(H,5,6)(H,7,8)/b;2-1-

Related Products

Other Form Products of Irsogladine (maleate)

Name CAS Formula Suppliers
Irsogladine 57381-26-7 C9H7Cl2N5 14

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Chemical and Physical Properties

Appearance: Melting point:181-182°C
Boiling point: Flash Point:
Water Solubility: Solubility:ethanol:37.22mg/mL;100mM;DMSO:37.22mg/mL;100mM;
Density: Merck:5102
BRN: Refractive Index:
Vapour: EINECS:
Optical Rotation: alpha:

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