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Meclizine (dihydrochloride)

(CAS: 1104-22-9)

Suppliers of Meclizine (dihydrochloride)

Company Name Email Tel Country
AdooQ BioScience, LLC [email protected] 855-GO-ADOOQ (855-462-3667) (US & Canada Toll Free) 866-930-6790 (US & Canada Toll Free) +1-323-389-9269 (Outside of US & Canada) USA

Fax: 866-333-9607 (US & Canada Toll Free) +1-323-606-8156 (Outside of US & Canada)Purity: Brand:

Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

Fax: +1 (847) 367-3681Purity: Brand:

Astatech, Inc. [email protected] +1 (215) 785-3197 USA

Fax: +1 (215) 785-2656Purity: Brand:

BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/100mg () USD96/5g ()

Cayman Chemical Company [email protected] Toll Free (USA and Canada Only): (800) 364-9897; Direct: (734) 971-3335;Technical Support Toll Free (USA and Canada Only): (888) 526-5351;Technical Support Direct: (734) 975-3888 USA

Fax: (734) 971-3640Purity: Brand:

D.K. Pharma Chem Pvt. Ltd. [email protected] +91 (251) 269-0111 India

Fax: +91 (251) 269-0366Purity: Brand:

Hangzhou Neway Chemicals Co., Ltd. [email protected] +86 (571) 8509-5566 China

Fax: +86 (571) 8509-5522Purity: Brand:

Huangshi Fuertai Chemical Co., Ltd. [email protected],[email protected] +86 (714) 639-2341 China

Fax: +86 (714) 639-2351Purity: Brand:

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/100mg () USD96/5g ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

Fax: 919-980-4831Purity: Brand:

Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD97/50mg (In stock)

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/100mg () USD96/5g ()

Shanghai Licheng Chemical Co., Ltd. [email protected],[email protected] +86 (21) 5756-1621 / +86 13671812677 / +86 13917221012 China

Fax: +86 (21) 5756-0637Purity: Brand:

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD20/2mg () USD42/10mg () USD86/50mg () USD122/200mg ()

Tocris Bioscience Inc. [email protected]; [email protected] +1 (636) 207-7651 USA

Fax: +1 (636) 207-7683Purity: Brand:

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Background Information of Meclizine (dihydrochloride)

Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness Target: Histamine H1 Receptor Meclizine is a histamine H1 receptor antagonist used to treat nausea and motion sickness, possesses anticholinergic, central nervous system depressant, and local anesthetic effects [1].

Solubility of Meclizine (dihydrochloride)

Solubility Sources
DMSO 1 mg/mL; Water <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 1 mg/mL (2.15 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM); In vivo 5% DMSO+95% Corn oil10 mg/mL Selleck Chemicals LLC
Soluble to 50 mM in DMSO Tocris Bioscience Inc.

Storage Condition of Meclizine (dihydrochloride)

Storage Condition Sources
Desiccate at RT Tocris Bioscience Inc.

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Neurological Disease

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Meclizine (dihydrochloride) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
463.87 C25H29Cl3N2 1104-22-9 1-[(4-Chlorophenyl)-phenylmethyl]-4-[(3-methylphenyl)methyl]piperazine dihydrochloride; 1-((4-chlorophenyl)(phenyl)methyl)-4-(3-methylbenzyl)piperazine dihydrochloride

Structure Information of Meclizine (dihydrochloride)

Smiles ClC1=CC=C(C=C1)C(C2=CC=CC=C2)N3CCN(CC4=CC=CC(C)=C4)CC3.Cl.Cl
InChI InChI=1S/C25H27ClN2.2ClH/c1-20-6-5-7-21(18-20)19-27-14-16-28(17-15-27)25(22-8-3-2-4-9-22)23-10-12-24(26)13-11-23;;/h2-13,18,25H,14-17,19H2,1H3;2*1H

Related Products

Other Form Products of Meclizine (dihydrochloride)

Name CAS Formula Suppliers
Meclozine 569-65-3 C25H28Cl2N2 3
Meclizine (dihydrochloride monohydrate) 31884-77-2 C25H31Cl3N2O 2

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Safety Data of Meclizine (dihydrochloride)

Hazard Symbols:Xn Risk Statements:22-63 Safety Statements:22-36
Transport Information: HS Code: RTECS:TL2005000
WGK Germany:3

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,4 mg/mLwarmed(8.62 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):5% DMSO+95% Corn oilFor best results, use promptly afte
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:214-164-8
Optical Rotation: alpha:

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