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Hydroxyzine (dihydrochloride)

(CAS: 2192-20-3)

Suppliers of Hydroxyzine (dihydrochloride)

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AA Blocks LLC [email protected] +1 858-523-8231

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AbMole BioScience [email protected] 1-800-660-8580 USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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Ark Pharm, Inc. [email protected] +1 (847) 367-3680 USA

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BOC Sciences [email protected] 1-631-504-6093

Fax: 1-631-614-7828Purity: >98% Brand: BOC Sciences

Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

Fax: 888-484-5008Purity: Brand:

Price and Availability: USD60/100mg () USD72/500mg ()

MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

Fax: 609-228-5909Purity: Brand:

Price and Availability: USD60/100mg () USD72/500mg ()
Quality Control & MSDS Files: HNMR LCMS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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Nanjing Qida International Trading Co., Ltd [email protected] 86-025-86460031 CHINA

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

Fax: +1-832-582-8590Purity: Brand:

Price and Availability: USD97/50mg (In stock)
Quality Control & MSDS Files: HPLC

Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

Fax: +86 (21) 5895-5996Purity: Brand:

Price and Availability: USD60/100mg () USD72/500mg ()

Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .98 Brand: TargetMol

Price and Availability: USD27/2mg () USD49/5mg () USD91/10mg () USD165/25mg () USD295/50mg ()

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Background Information of Hydroxyzine (dihydrochloride)

Hydroxyzine Dihydrochloride is a histamine H1-receptor antagonist. Target: Histamine H1-Receptor Hydroxyzine inhibits carbachol (10 μM)-induced serotonin release by 34% at 10 μM, by 25% 1 μM and by 17% 0.1 μM in pretreated bladder slices for 60 min [1].

Solubility of Hydroxyzine (dihydrochloride)

Solubility Sources
DMSO <1 mg/mL; Water 550 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 90 mg/mL (200.96 mM); Water90 mg/mL (200.96 mM); Ethanol15 mg/mL (33.49 mM); In vivo Saline30 mg/mL Selleck Chemicals LLC

Storage Condition of Hydroxyzine (dihydrochloride)

Storage Condition Sources

MSDS Information

MSDS Sources

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Immunology/Inflammation GPCR/G Protein
Target Histamine Receptor
Research Area Inflammation/Immunology

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Hydroxyzine (dihydrochloride) - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
447.83 C21H29Cl3N2O2 2192-20-3 2-[2-[4-[(4-Chlorophenyl)phenymethyl]-1-piperazinyl]ethoxy]ethanol dihydrochloride; 2-(2-(4-((4-chlorophenyl)(phenyl)methyl)piperazin-1-yl)ethoxy)ethanol dihydrochloride

Structure Information of Hydroxyzine (dihydrochloride)

Smiles ClC1=CC=C(C=C1)C(C2=CC=CC=C2)N3CCN(CCOCCO)CC3.Cl.Cl
InChI InChI=1S/C21H27ClN2O2.2ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25;;/h1-9,21,25H,10-17H2;2*1H

Related Products

Other Form Products of Hydroxyzine (dihydrochloride)

Name CAS Formula Suppliers
Hydroxyzine 68-88-2 C21H27ClN2O2 10
Hydroxyzine (D4' dihydrochloride) 1219805-91-0 C21H25D4Cl3N2O2 2

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Safety Data of Hydroxyzine (dihydrochloride)

Hazard Symbols:Xn Risk Statements:R22;R36/37/38 Safety Statements:S26
Transport Information: HS Code: RTECS:KK2280000
WGK Germany:3

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:190-192°C
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,90 mg/mL(200.96 mM);In vitro:Water,90 mg/mL(200.96 mM);In vitro:Ethanol,15 mg/mL(33.49 mM);In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):SalineFor best results, use promptly af
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:218-586-3
Optical Rotation: alpha:

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