Flavoxate (hydrochloride)
(CAS: 3717-88-2)
Suppliers of Flavoxate (hydrochloride)
Background Information of Flavoxate (hydrochloride)
Flavoxate Hydrochloride(DW-61 Hydrochloride) is a muscarinic AChR antagonist used in various urinary syndromes and as an antispasmodic.
Target: mAChR
Flavoxate displaces [3H]nitrendipine on the Ca2+ channels binding sites with IC50 of 254 μM [1].
Solubility of Flavoxate (hydrochloride)
Solubility |
Sources |
DMSO 3 mg/mL; Water 10 mg/mL |
MedChemexpress Co., Ltd.
|
(25°C) * In vitro DMSO 3 mg/mL (7.01 mM); Water10 mg/mL (23.36 mM); Ethanol<1 mg/mL (<1 mM); In vivo 30% Propylene glycol, 5% Tween 80, 65% D5W30 mg/mL |
Selleck Chemicals LLC
|
Storage Condition of Flavoxate (hydrochloride)
Storage Condition |
Sources |
Quality Control and Spectral Data
Mechanism and Indications
Chemical Information
M.Wt |
Formula |
CAS No. |
Synonyms |
427.92 |
C24H26ClNO4 |
3717-88-2 |
3-Methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylic acid 2-(1-piperidinyl)ethyl ester hydrochloride; 2-(piperidin-1-yl)ethyl 3-methyl-4-oxo-2-phenyl-4H-chromene-8-carboxylate hydrochloride |
Structure Information of Flavoxate (hydrochloride)
Smiles |
O=C1C2=C(OC(C3=CC=CC=C3)=C1C)C(C(OCCN4CCCCC4)=O)=CC=C2.Cl |
InChI |
InChI=1S/C24H25NO4.ClH/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25;/h2,4-5,8-12H,3,6-7,13-16H2,1H3;1H |
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CAS |
Formula |
Suppliers |
Safety Data of Flavoxate (hydrochloride)
Chemical and Physical Properties
Appearance:White to off-white Solid |
Melting point:232-234°C |
Boiling point: |
Flash Point: |
Water Solubility: |
Solubility:In vitro:Water,10 mg/mL(23.36 mM);In vitro:DMSO,3 mg/mL(7.01 mM);In vitro:Ethanol,Insoluble;In vivo:Add solvents to the product individually and in order(Data is from Selleck tests instead of citations):30% propylene glycol, 5% Tween 80, 65% D5WFor best r |
Density: |
Merck: |
BRN: |
Refractive Index: |
Vapour: |
EINECS:223-066-4 |
Optical Rotation: |
alpha: |
Reference
[1].Dansette, P.M., M. Jaoen, and C. Pons, HMG-CoA reductase activity in human liver microsomes: comparative inhibition by statins. Exp Toxicol Pathol, 2000. 52(2): p. 145-8.
[2].Kimura, Y., et al., Mechanisms of the suppression of the bladder activity by flavoxate. Int J Urol, 1996. 3(3): p. 218-27.
[3].Oka, M., et al., Brain pertussis toxin-sensitive G proteins are involved in the flavoxate hydrochloride-induced suppression of the micturition reflex in rats. Brain Res, 1996. 727(1-2): p. 91-8.