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Gliclazide

(CAS: 21187-98-4)

Suppliers of Gliclazide

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AA Blocks LLC [email protected] +1 858-523-8231

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AbMole BioScience [email protected] 1-800-660-8580 USA

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Apexbio Technology LLC [email protected] +1-832-696-8203 USA

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BOC Sciences [email protected] 1-631-504-6093

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Biochempartner Co., Ltd [email protected] 0086-13720134139; 0086-15971444841 China

Fax: Purity: 0.98 Brand: Biochempartner

CHEMSCENE, LLC [email protected] 732-484-9848 USA

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Price and Availability: USD83/1g () USD121/5g ()

Dragonfarm Co., Ltd. [email protected] +86 (571) 8589-9500 / 8589-9501 / 8589-9568 China

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Iffect Chemphar Co., Ltd. [email protected] +86 (755) 8376-1609 China

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MedChemexpress Co., Ltd. [email protected] 609-228-6898 USA

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Price and Availability: USD83/1g () USD121/5g ()
Quality Control & MSDS Files: HNMR LCMS MSDS

MedKoo Biosciences, Inc. [email protected] 919-279-0682 USA

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SOCOSUR Distribution Company [email protected] +33 (1) 4772-0075 France

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Selleck Chemicals LLC [email protected] +1-832-582-8158 USA

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Price and Availability: USD97/50mg (In stock) USD130/10mM/1mLIn DMSO (In stock)
Quality Control & MSDS Files: HNMR HPLC HNMR HPLC HPLC

Shandong Fangming Pharmaceutical Group Co., Ltd. [email protected],[email protected] +86 (530) 720-8439 / 519-8388 China

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Shanghai Haoyuan Chemexpress Co., Ltd. [email protected] +86 (21) 5187-0955 / +86 (21) 5895-5995 China

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Shanghai Orient Chemical Co., Ltd. [email protected],[email protected] +86 (21) 5996-9669 China

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Target Molecule Corp. [email protected] (857) 239-0968 USA

Fax: 857-239-8801Purity: .99 Brand: TargetMol

Price and Availability: USD20/2mg () USD42/10mg () USD75/50mg () USD122/200mg ()

Wuhan Pharma Chemical Co., Ltd. [email protected] +86 (27) 8771-1369 China

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Background Information of Gliclazide

Gliclazide is a whole-cell beta-cell ATP-sensitive potassium currents blocker with an IC50 of 184 nM. Target: Potassium Channel gliclazide further characterize its mechanism of hypoglycemic effect: the observed improvements in insulin sensitivity and in GLUT4 translocation indicate that gliclazide counters the hydrogen peroxide-induced insulin resistance in 3T3L1 adipocytes and also would further augment the hypoglycemic effect of this drug as insulinotropic sulfonylurea [1].

Solubility of Gliclazide

Solubility Sources
DMSO 65 mg/mL; Water <1 mg/mL MedChemexpress Co., Ltd.
(25°C) * In vitro DMSO 65 mg/mL (200.98 mM); Water<1 mg/mL (<1 mM); Ethanol<1 mg/mL (<1 mM) Selleck Chemicals LLC

Storage Condition of Gliclazide

Storage Condition Sources

MSDS Information

MSDS Sources
MedChemexpress Co., Ltd.

Quality Control and Spectral Data

QC Reports Sources
[HNMR] [LCMS] MedChemexpress Co., Ltd.
[HNMR] [HPLC] Selleck Chemicals LLC

Mechanism and Indications

Signaling Pathways Membrane Transporter/Ion Channel
Target Potassium Channel
Research Area Cardiovascular Disease
Indications

Clinical Information

Product Name Sponsor & Collaborators Indications Start Date End Date Phase
Gliclazide - Launched

Chemical Information

M.Wt Formula CAS No. Synonyms
323.41 C15H21N3O3S 21187-98-4 1-(3-Azabicyclo[3.3.0]oct-3-yl)-3-p-tolylsulphonylurea; N-((hexahydrocyclopenta[c]pyrrol-2(1H)-yl)carbamoyl)-4-methylbenzenesulfonamide

Structure Information of Gliclazide

Smiles O=C(NS(C1=CC=C(C)C=C1)(=O)=O)NN2CC(CCC3)C3C2
InChI InChI=1S/C15H21N3O3S/c1-11-5-7-14(8-6-11)22(20,21)17-15(19)16-18-9-12-3-2-4-13(12)10-18/h5-8,12-13H,2-4,9-10H2,1H3,(H2,16,17,19)

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Safety Data of Gliclazide

Hazard Symbols:Xn,Xi Risk Statements:21-36/38-46-62-63 Safety Statements:25-26-36/37-53
Transport Information: HS Code: RTECS:YT4500000
WGK Germany:2

Chemical and Physical Properties

Appearance:White to off-white Solid Melting point:163-169 °C(lit.)
Boiling point: Flash Point:
Water Solubility: Solubility:In vitro:DMSO,65 mg/mL(200.98 mM);In vitro:Water,Insoluble;In vitro:Ethanol,Insoluble;
Density: Merck:
BRN: Refractive Index:
Vapour: EINECS:244-260-5
Optical Rotation: alpha:

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